Potassium channels are transmembrane proteins that selectively facilitate the flow of
potassium ions down an electrochemical gradient. These molecules have been studied in …

Since the discovery of the participation of various ion channels in the regulation of cell
proliferation and programmed cell death two decades ago, the field exploring ion channel …

Background Barely 10-20% of patients with metastatic colorectal cancer (mCRC) receive a
clinical benefit from the use of anti-EGFR monoclonal antibodies (mAbs). We hypothesized …

The SK3 channel, a potassium channel, was recently shown to control cancer cell migration,
a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel …

The remodeling of calcium homeostasis contributes to the cancer hallmarks and the
molecular mechanisms involved in calcium channel regulation in tumors remain to be …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Background Recent genome-wide association studies (GWAS) have identified more than
100 loci associated with increased risk of prostate cancer, most of which are in non-coding …

The primacy of lipids as essential components of cellular membranes is conserved across
taxonomic domains. In addition to this crucial role as a semi-permeable barrier, lipids are …

Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …

Synthetic alkyl lipids, such as the ether lipids edelfosine (1-O-octadecyl-2-O-methyl-rac-
glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β …