Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause
of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as …

Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

Increasing evidence suggests that inflammatory responses are involved in the progression
of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage …

Brain injuries are devastating conditions, representing a global cause of mortality and
morbidity, with no effective treatment to date. Increased evidence supports the role of …

Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …

Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to
increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug …

Glycyrrhizin (glycyrrhizic acid), a bioactive triterpenoid saponin constituent of Glycyrrhiza
glabra, is a traditional medicine possessing a plethora of pharmacological anti-inflammatory …

Background Cognitive impairment in the late stage of traumatic brain injury (TBI) is
associated with the NOD-, LRR and pyrin domain-containing protein 3 (NLRP3) …

High-mobility group box-1 (HMGB1) is a nuclear protein associated with early inflammatory
changes upon extracellular secretion expressed in various cells, including neurons and …