Simple Summary The patient-derived xenograft (PDX) model is the in vivo standard for
cancer research as a preclinical platform. Besides its merits, we describe the general …

Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived …

Endometriosis is a fascinating disease that we strive to better understand. Molecular
techniques are shedding new light on many important aspects of this disease: from …

Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One …

Small cell lung cancer is initially highly responsive to cisplatin and etoposide but in almost
every case becomes rapidly chemoresistant, leading to death within 1 year. We modeled …

Access to clinically relevant small cell lung cancer (SCLC) tissue is limited because surgical
resection is rare in metastatic SCLC. Patient-derived xenografts (PDX) and circulating tumor …

Cancer is a leading cause of death across the world and continues to increase in incidence.
Despite years of research, multiple tumors (eg, glioblastoma, pancreatic cancer) still have …

Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is a
prevalent post-translational modification (PTM) that regulates diverse cellular processes …

Lung cancer organoids (LCOs) have sprung up in more and more researching fields,
because of their ability to recapitulate the three-dimensional structure and functions of the in …

With a five-year survival rate of 9%, pancreatic ductal adenocarcinoma (PDAC) is the
deadliest of all cancers. The rapid mortality makes PDAC difficult to research, and inspires a …