The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

Oxidative stress has a significant impact on the development and progression of common
human pathologies, including cancer, diabetes, hypertension and neurodegenerative …

Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency.
Here, we report on the generation of a human WS model in human embryonic stem cells …

Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory
roles in human cancer biology. In our study, we found that lncRNA CCAT1, whose …

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …

Background Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical
unloading is associated with serious health consequences. Long non‐coding RNAs …

DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical
microprocessor complex for microRNA biogenesis. However, the non-canonical functions of …

Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of
proteins and organelles. Although the autophagy regulation machinery has been widely …

The mammalian genome is packaged into chromatin that is further compacted into three‐
dimensional structures consisting of distinct functional domains. The higher order structure …

Lysine methylation is a common posttranslational modification (PTM) of histones that is
important for the epigenetic regulation of transcription and chromatin in eukaryotes …