The epithelium in inflamed intestinal segments of patients with Crohn's disease is
characterized by a reduction of tight junction strands, strand breaks, and alterations of tight …

Here, we discuss the principles of allosteric activating mutations, propagation downstream of
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …

A new method has been developed to detect functional relationships among proteins
independent of a given sequence or fold homology. It is based on the idea that protein …

A novel ligand-binding domain, named the 'ACT domain', was recently identified by a PSI-
BLAST search. The archetypical ACT domain is the C-terminal regulatory domain of 3 …

The shikimate pathway has been described as a metabolic tree with many branches that led
to the synthesis of an extensive range of products. This pathway is present only in bacteria …

The first comprehensive coverage of all facets of the Claisen rearrangement and its variants.
As such, this book helps synthetic chemists to exploit the vast potential of this elegant CC …

Natural enzymes have arisen over millions of years by the gradual process of Darwinian
evolution. The fundamental steps of evolution—mutation, selection, and amplification—can …

Fungi-induced plant diseases affect global food security and plant ecology. The biotrophic
fungus Ustilago maydis causes smut disease in maize (Zea mays) plants by secreting …

Allostery is a major driver of biological processes requiring coordination. Thus, it is one of
the most fundamental and remarkable phenomena in nature, and there is motivation to …

Only a very few examples of enzymes known to catalyze pericyclic reactions have been
reported, and presently no enzyme has been demonstrated unequivocally to catalyze a …