The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Fifteen years of genetic research in Parkinson's disease (PD) have led to the identification of
several monogenic forms of the disorder and of numerous genetic risk factors increasing the …

This study aimed to determine the mutational spectrum of familial Parkinson's disease and
sporadic early-onset Parkinson's disease (sEOPD) in a mainland Chinese population and …

The past two decades in research has revealed the importance of leucine-rich repeat kinase
2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families …

The past 15 years has witnessed tremendous progress in our understanding of the genetic
basis for Parkinson's disease (PD). Notably, whereas most mutations, such as those in …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

To date, molecular genetic analyses have identified over 500 distinct DNA variants in five
disease genes associated with familial Parkinson disease; α‐synuclein (SNCA), parkin …

Mutations associated with leucine-rich repeat kinase 2 are the most common known cause
of Parkinson's disease. The known expression of leucine-rich repeat kinase 2 in immune …

Several recent studies have shown that dementia is common in Parkinson's disease (PD),
and that in some patients, cognitive impairment occurs even at the time of diagnosis. The …

Abstract Parkinson's disease (PD), like many common age-related conditions, has been
recognized to have a substantial genetic component. Multiple lines of evidence suggest that …