Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

RNA structure is crucial for gene regulation and function. In the past, transcriptomes have
largely been parsed by primary sequences and expression levels, but it is now becoming …

Self-assembling RNA molecules present compelling substrates for the rational interrogation
and control of living systems. However, imperfect in silico models—even at the secondary …

Genome-wide association studies (GWAS) often identify disease-associated mutations in
intergenic and non-coding regions of the genome. Given the high percentage of the human …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

The series of RNA folding events that occur during transcription can critically influence
cellular RNA function. Here, we present reconstructing RNA dynamics from data (R2D2), a …

RNA folds into intricate structures that enable its pivotal roles in biology, ranging from
regulation of gene expression to ligand sensing and enzymatic functions. Therefore …

RNA secondary structure prediction is widely used for developing hypotheses about the
structures of RNA sequences, and structure can provide insight about RNA function. The …

Transcriptomics experiments and computational predictions both enable systematic
discovery of new functional RNAs. However, many putative noncoding transcripts arise …

RNA–protein interactions differ from DNA–protein interactions because of the central role of
RNA secondary structure. Some RNA‐binding domains (RBDs) recognize their target sites …