Colorectal cancer is a complex disease resulting from somatic genetic and epigenetic
alterations, including locus-specific CpG island methylation and global DNA or LINE-1 …

Although the incidence of colorectal cancer in Iranian older age subjects is currently very
low compared to Western population, the younger generation is experiencing an …

The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the
disease resulted from the accumulation of mutations in oncogenes and tumor suppressor …

Significance: The progressive, dose-dependent, and potentially reversible epigenetic
changes observed in cancer present new opportunities in cancer risk modification and …

Alzheimer's disease (AD) represents the most common form of dementia in the elderly,
characterized by progressive loss of memory and cognitive capacity severe enough to …

Vitamin B12 has been widely related to methionine metabolism, which is an essential
component for biological methylation reactions, including DNA methylation. However, the …

There are conflicting reports regarding the association between DNA methyltransferases
(DNMTs) expression and global or gene‐specific DNA methylation in colorectal cancer …

Background. The objective was to determine whether relationships exist between the
methylene‐tetrahydrofolate reductase (MTHFR) polymorphisms and risk of colorectal cancer …

Background The 677C> T polymorphism of methylenetetrahydrofolate reductase (MTHFR)
gene is considered to have a significant effect on colorectal cancer susceptibility, but the …

We evaluated the promoter methylation levels of the APC, MGMT, h MLH1, RASSF1A and
CDKN2A genes in 107 colorectal cancer (CRC) samples and 80 healthy adjacent tissues …