Interventions to prevent pregnancy complications have been largely unsuccessful. We
suggest this is because the foundation for a healthy pregnancy is laid prior to the …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

Decidual remodelling of midluteal endometrium leads to a short implantation window after
which the uterine mucosa either breaks down or is transformed into a robust matrix that …

During the implantation window, the endometrium becomes poised to transition to a
pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC) …

Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the
endometrium before the placental trophoblast invades beyond the uterine mucosa into the …

BACKGROUND Human pregnancy requires robust hemostasis to prevent hemorrhage
during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification …

A major challenge in biology is determining how evolutionarily novel characters originate;
however, mechanistic explanations for the origin of new characters are almost completely …

Deep placentation in the human requires physiologic transformation of the spiral arteries
into uteroplacental vessels. This process involves the inner myometrial segment (junctional …

Intensive research work has been performed to better understand the regulation of the
endometrium and its clinical implications to improve implantation. Although many proteins …

Prolactin (PRL) is an important hormone with many diverse functions. Although it is
predominantly produced by lactrotrophs of the pituitary there are a number of other organs …