Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac
fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms …

One of the defining features of the liver is the capacity to maintain a constant size despite
injury. Although the precise molecular signals involved in the maintenance of liver size are …

Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in
the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the …

The unique ability of the liver to regenerate itself has fascinated biologists for years and has
made it the prototype for mammalian organ regeneration. Harnessing this process has great …

Hepatic oval cells are considered to be facultative hepatic stem cells (HSCs) that
differentiate into hepatocytes and cholangiocytes in severely injured liver. Hepatic oval cells …

Liver fibrosis results from chronic injury of hepatocytes and activation of Collagen Type I
producing myofibroblasts that produce fibrous scar in liver fibrosis. Myofibroblasts are not …

The liver is a unique organ with a remarkably high potential to regenerate upon injuries. In
severely damaged livers where hepatocyte proliferation is impaired, facultative liver …

Abstract Background and Aims In liver fibrosis, myofibroblasts derive from HSCs and as yet
undefined mesenchymal cells. We aimed to identify portal mesenchymal progenitors of …

Recent progress in the field of the stem cell research has given new hopes to treat and even
cure diverse degenerative disorders and incurable diseases in human. Particularly, the …

In chronic liver injury, liver progenitor cells (LPCs) proliferate in the periportal area, migrate
inside the lobule, and undergo further differentiation. This process is associated with …