Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Anemia of inflammation (AI), also known as anemia of chronic disease (ACD), is regarded
as the most frequent anemia in hospitalized and chronically ill patients. It is prevalent in …

Abstract Iron deficiency anemia affects> 1.2 billions individuals worldwide, and iron
deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Iron is an essential trace element for multicellular organisms and nearly all microorganisms.
Although iron is abundant in the environment, common forms of iron are minimally soluble …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte
production. High hepcidin levels block intestinal iron absorption and macrophage iron …

Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …