Like other HIV-1 auxiliary proteins, Vpr is conserved within all the human (HIV-1, HIV-2) and
simian (SIV) immunodeficiency viruses. However, Vpr and homologous HIV-2, and SIV Vpx …

Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of
ubiquitin to a target protein acts as a reversible post-translational modification functionally …

The HIV-1 accessory protein Vpr is required for efficient viral infection of macrophages and
promotion of viral replication in T cells. Vpr's biological activities are closely linked to the …

HIV replication in nondividing host cells occurs in the presence of high concentrations of
noncanonical dUTP, apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 …

We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains
high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A …

Throughout the HIV-1 replication cycle, complex host-pathogen interactions take place in the
infected cell, leading to the production of new virions. The virus modulates the host cellular …

Viral protein R (Vpr) is an HIV-1 accessory protein whose function remains poorly
understood. In this report, we sought to determine the requirement of Vpr for facilitating HIV …

HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes.
Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to …

Abstract Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is
potentially involved in the infection of macrophages and the induction of the ataxia …

A novel fluorescent nanosensor has been developed by combining super fluorescence
quenching ability of graphene oxide and hybridization chain reaction amplification, which …