Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Aims Exercise confers protection against cardiovascular ageing, but the mechanisms remain
largely unknown. This study sought to investigate the role of fibronectin type-III domain …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

Sex characteristics exhibit significant disparities in various human diseases, including
prevalent cardiovascular diseases, cancers, metabolic disorders, autoimmune diseases …

Sirtuin 6 (SIRT6) is an NAD-dependent deacetylase/deacylase/mono-ADP
ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in …

Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality.
These diseases have a multifaceted nature being influenced by a multitude of biochemical …