In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

Abstract Purpose of Review Novel 3D organoid culture techniques have enabled long-term
expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the …

Organoids have become one of the fastest progressing and applied models in biological
and medical research, and various organoids have now been developed for most of the …

Recent breakthroughs in developing human-relevant organotypic models led to the building
of highly resemblant tissue constructs that hold immense potential for transplantation, drug …

Organoids can be regarded as a beneficial tool for discovery of new therapeutics for
diabetes and/or maturation of pancreatic progenitors (PP) towards β cells. Here, we devised …

Diabetes mellitus is associated with defects in islet β-cell functioning and consequent
hyperglycemia resulting in multi-organ damage. Physiologically relevant models that mimic …

Pancreas organogenesis depends on proper interactions of endoderm-derived epithelial
cells, which will form the exocrine and endocrine cells of the adult organ, with their …

Mesenchymal–epithelial crosstalk plays a crucial role in organ development and stem cell
function. However, the identity of the mesenchymal cells involved in this exchange was …