Migratory cells are polarized with protrusive fronts and contractile rears. This spatial
organization necessitates long-range coordination of the signals that organize protrusions …

Bleb-based migration, a conserved cell motility mode, has a crucial role in both
physiological and pathological processes. Unlike the well-elucidated mechanisms of …

Tissue-resident CD8+ T cells (TRM) continuously scan peptide-MHC (pMHC) complexes in
their organ of residence to intercept microbial invaders. Recent data showed that TRM …

Effective immunity requires a large, diverse naive T cell repertoire circulating among
lymphoid organs in search of antigen. Sphingosine 1-phosphate (S1P) and its receptor …

Motility is a crucial activity of immune cells allowing them to patrol tissues as they
differentiate, sample or exchange information, and execute their effector functions. Although …

Adenomatous polyposis coli (APC) is a tumor suppressor whose mutations underlie familial
adenomatous polyposis (FAP) and colorectal cancer. Although its role in intestinal epithelial …

In lymphopenic environments, secondary lymphoid organs regulate the size of B and T cell
compartments by supporting the homeostatic proliferation of mature lymphocytes. The …

Leukocytes patrol our bodies in search of pathogens and migrate to sites of injury in
response to various stimuli. Rapid and directed leukocyte motility is therefore crucial to our …

Confined cells migrating through 3D environments are also constrained by the laws of
physics, meaning for every action there must be an equal and opposite reaction for cells to …

When the plasma membrane (PM) detaches from the underlying actin cortex, the PM
expands according to intracellular pressure and a spherical membrane protrusion called a …