Abstract Gelsolin, a Ca2+‐regulated actin filament severing, capping, and nucleating
protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More …

Protein misassembly into aggregate structures, including cross-β-sheet amyloid fibrils, is
linked to diseases characterized by the degeneration of post-mitotic tissue. While amyloid …

Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion
diseases to dementias, but are also encountered in several functional contexts. Yet, the …

Isosteric replacement of amide bond (s) of peptides with surrogate groups is an important
strategy for the synthesis of peptidomimetics (pseudo-peptides). Triazole is a well …

We present a case of a 75-year-old woman who presented with progressive kidney failure.
Kidney biopsy performed to determine the cause of kidney failure showed amyloidosis of …

Gelsolin amyloidosis is an autosomal dominant incurable disease caused by a point
mutation in the GSN gene (G654A/T), specifically affecting secreted plasma gelsolin …

Glycosaminoglycans (GAGs) are highly sulfated linear polysaccharides prevalent in the
extracellular matrix, and they associate with virtually all amyloid deposits in vivo. GAGs …

The misfolding of normally soluble proteins causes their aggregation and deposition in the
tissues which disrupts the normal structure and function of the corresponding organs. The …

AGel amyloidosis, formerly known as familial amyloidosis of the Finnish-type, is caused by
pathological aggregation of proteolytic fragments of plasma gelsolin. So far, four mutations …

Gelsolin amyloidosis is a rare type of amyloidosis typically involving the cranial and
peripheral nerves, but rarely the kidney. Here we report the clinical, kidney biopsy, and mass …