[HTML][HTML] Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Mechanisms and consequences of Jak–STAT signaling in the immune system
AV Villarino, Y Kanno, JJ O'Shea - Nature immunology, 2017 - nature.com
Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
Genomic profiling for clinical decision making in lymphoid neoplasms
L De Leval, AA Alizadeh, PL Bergsagel… - Blood, The Journal …, 2022 - ashpublications.org
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
The 2016 revision of the World Health Organization classification of lymphoid neoplasms
SH Swerdlow, E Campo, SA Pileri… - Blood, The Journal …, 2016 - ashpublications.org
A revision of the nearly 8-year-old World Health Organization classification of the lymphoid
neoplasms and the accompanying monograph is being published. It reflects a consensus …
neoplasms and the accompanying monograph is being published. It reflects a consensus …
The JAK-STAT pathway: impact on human disease and therapeutic intervention
JJ O'Shea, DM Schwartz, AV Villarino… - Annual review of …, 2015 - annualreviews.org
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …
transcription factors that mediate intracellular signaling that is usually generated at cell …
LGL leukemia: from pathogenesis to treatment
T Lamy, A Moignet… - Blood, The Journal of the …, 2017 - ashpublications.org
Large granular lymphocyte (LGL) leukemia has been recognized by the World Health
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …
[HTML][HTML] Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …
The genetic basis of myelodysplasia and its clinical relevance
M Cazzola, MG Della Porta… - Blood, The Journal of the …, 2013 - ashpublications.org
Myelodysplasia is a diagnostic feature of myelodysplastic syndromes (MDSs) but is also
found in other myeloid neoplasms. Its molecular basis has been recently elucidated by …
found in other myeloid neoplasms. Its molecular basis has been recently elucidated by …