Chitosan is an antimicrobial, biodegradable and biocompatible natural polymer,
commercially derived from the partial deacetylation of chitin. Currently modified chitosan has …

During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole
ring are readily able to bind with a variety of enzymes and receptors in biological system via …

Among the different extraction techniques used at analytical and preparative scale,
supercritical fluid extraction (SFE) is one of the most used. This review covers the most …

Cyclodextrins are cyclic oligosaccharides able to form inclusion complexes with a variety of
hydrophobic guest molecules, positively modifying their physicochemical properties. A …

The main mechanism for drug-drug interaction is displacement reaction of ligands from their
protein binding sites. The aim of this study was to evaluate anticancer drug sorafenib …

The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with
poor solubility and reasonable permeability is limited by the drug dissolution step from drug …

Azole compounds are an important class of nitrogen heterocycles with electron-rich
property. This special structure endows azole-based derivatives easily bind with the …

Abstract Development of efficient ocular delivery nanosystems remains a major challenge to
achieve sustained therapeutic effect. The purpose of this work was to develop chitosan …

The real problem in pharmaceutical preparation is drugs' poor aqueous solubility, low
permeability through biological membranes, and short biological t1/2. Conventional drug …