Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

Highlights•Kinetic models are crucial to understand complex dynamic processes.•Not all
model parameters need to be known precisely due to overlapping regulatory …

Global energy demand and environmental concerns have stimulated increasing efforts to
produce carbon-neutral fuels directly from renewable resources. Microbially derived …

Transcriptional reprogramming of cellular metabolism is a hallmark of cancer. However,
systematic approaches to study the role of transcriptional regulators (TRs) in mediating …

In most conditions, glucose is the best carbon source for E. coli: it provides faster growth
than other sugars and is consumed first in sugar mixtures. Here we identify conditions in …

Engineering metabolic biosynthetic pathways has enabled the microbial production of many
useful chemicals. However, pathway productivities and yields are often limited by metabolic …

One of the key ways in which microbes are thought to regulate their metabolism is by
modulating the availability of enzymes through transcriptional regulation. However, the …

The optimization of cellular functions often requires the balancing of gene expression, but
the physical construction and screening of alternative designs are costly and time …

Microbes must ensure robust amino acid metabolism in the face of external and internal
perturbations. This robustness is thought to emerge from regulatory interactions in metabolic …

Gene expression is regulated by specific transcriptional circuits but also by the global
expression machinery as a function of growth. Simultaneous specific and global regulation …