Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

The plant immune system is fundamental for plant survival in natural ecosystems and for
productivity in crop fields. Substantial evidence supports the prevailing notion that plants …

NOD-like receptor (NLR), family pyrin domain containing 3 (NLRP3) assembles a protein
complex known as the NLRP3 inflammasome upon sensing certain pathogen products or …

The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns …

Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …

Parkinson's disease (PD) is characterized by a profound loss of dopaminergic neurons in
the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction …