Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

Many spatially resolved transcriptomic technologies do not have single-cell resolution but
measure the average gene expression for each spot from a mixture of cells of potentially …

As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

Glioblastoma (GBM) treatment has remained almost unchanged for more than 20 years. The
current standard of care involves surgical resection (if possible) followed by concomitant …

Synapses between engram cells are believed to be substrates for memory storage, and the
weakening or loss of these synapses leads to the forgetting of related memories. We found …

Microglia are increasingly recognized for their major contributions during brain development
and neurodegenerative disease. It is currently unknown whether these functions are carried …

Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …