Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of
cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal …

Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

Hinds and Stec Bilirubin Signaling 789 protein, which results in enhanced phosphorylation,
transactivation, and DNA binding to PPAR response elements in promoters or enhancers of …

Bilirubin is a yellow-colored metabolite of heme degradation (a bile pigment), once believed
to be toxic, but recently recognized as a powerful endogenous antioxidant of physiologic …

Rationale: The therapeutic benefits of bilirubin in the treatment of ulcerative colitis (UC) are
considerable, whereas the underlying mechanism of bilirubin on UC remains unclear …

Several population studies have observed lower serum bilirubin levels in patients with non-
alcoholic fatty liver disease (NAFLD). Yet, treatments to target this metabolic phenotype have …

Abstract Purpose of Review To discuss recent advances indicating that bilirubin safeguards
against cardiorenal and metabolic diseases. Recent Findings Several investigations from …

Bromo-4, 6-dinitroaniline (BDNA) is a widespread azo-dye-related hazardous pollutant.
However, its reported adverse effects are limited to mutagenicity, genotoxicity, endocrine …

We have previously shown that body mass index attenuates a positive association of platelet
count (PLT) and inverse of mean platelet volume (MPV) with lung cancer risk in men. It is …