Engaging innate immunity in HIV-1 cure strategies
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
Regulation of ligands for the NKG2D activating receptor
NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …
as a major recognition receptor for detection and elimination of transformed and infected …
Latency reversal plus natural killer cells diminish HIV reservoir in vivo
JT Kim, TH Zhang, C Carmona, B Lee, CS Seet… - Nature …, 2022 - nature.com
HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …
Effect of NKG2D ligand expression on host immune responses
M Champsaur, LL Lanier - Immunological reviews, 2010 - Wiley Online Library
Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …
HIV-1 adaptation to NK-cell-mediated immune pressure
G Alter, D Heckerman, A Schneidewind, L Fadda… - Nature, 2011 - nature.com
Natural killer (NK) cells have an important role in the control of viral infections, recognizing
virally infected cells through a variety of activating and inhibitory receptors,,. Epidemiological …
virally infected cells through a variety of activating and inhibitory receptors,,. Epidemiological …
NKG2D ligands as therapeutic targets
P Spear, MR Wu, ML Sentman, CL Sentman - Cancer immunity, 2013 - AACR
Abstract The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting
the host from infections and cancer. By recognizing ligands induced on infected or tumor …
the host from infections and cancer. By recognizing ligands induced on infected or tumor …
SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D
Natural killer (NK) cells are cytotoxic effector cells that target and lyse virally infected cells;
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …
HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention
M Kogan, J Rappaport - Retrovirology, 2011 - Springer
The HIV protein, Vpr, is a multifunctional accessory protein critical for efficient viral infection
of target CD4+ T cells and macrophages. Vpr is incorporated into virions and functions to …
of target CD4+ T cells and macrophages. Vpr is incorporated into virions and functions to …
New insights into HIV-1-primary skin disorders
F Cedeno-Laurent, M Gómez-Flores, N Mendez… - Journal of the …, 2011 - Springer
Since the first reports of AIDS, skin involvement has become a burdensome stigma for
seropositive patients and a challenging task for dermatologist and infectious disease …
seropositive patients and a challenging task for dermatologist and infectious disease …
Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu
AH Shah, B Sowrirajan, ZB Davis, JP Ward… - Cell host & …, 2010 - cell.com
Natural killer (NK) cell degranulation in response to virus-infected cells is triggered by
interactions between invariant NK cell surface receptors and their ligands on target cells …
interactions between invariant NK cell surface receptors and their ligands on target cells …