Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Calcium signaling in astrocytes and gliotransmitter release

J Goenaga, A Araque, P Kofuji… - Frontiers in synaptic …, 2023 - frontiersin.org
Glia are as numerous in the brain as neurons and widely known to serve supportive roles
such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and …

The ATP level in the medial prefrontal cortex regulates depressive-like behavior via the medial prefrontal cortex-lateral habenula pathway

S Lin, L Huang, Z Luo, X Li, S Jin, Z Du, D Wu… - Biological …, 2022 - Elsevier
Background Depression is the most common mental illness. Mounting evidence suggests
that dysregulation of extracellular ATP (adenosine triphosphate) is involved in the …

Aberrant calcium signals in reactive astrocytes: a key process in neurological disorders

E Shigetomi, K Saito, F Sano, S Koizumi - International journal of …, 2019 - mdpi.com
Astrocytes are abundant cells in the brain that regulate multiple aspects of neural tissue
homeostasis by providing structural and metabolic support to neurons, maintaining synaptic …

Calcium signals in astrocyte microdomains, a decade of great advances

A Lia, VJ Henriques, M Zonta, A Chiavegato… - Frontiers in cellular …, 2021 - frontiersin.org
The glial cells astrocytes have long been recognized as important neuron-supporting
elements in brain development, homeostasis, and metabolism. After the discovery that the …

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer's disease

A Lia, G Sansevero, A Chiavegato, M Sbrissa… - Nature …, 2023 - nature.com
Calcium dynamics in astrocytes represent a fundamental signal that through gliotransmitter
release regulates synaptic plasticity and behaviour. Here we present a longitudinal study in …

Two decades of astrocytes in neurovascular coupling

A Lia, A Di Spiezio, M Speggiorin… - Frontiers in Network …, 2023 - frontiersin.org
The brain is a highly energy demanding organ, which accounts in humans for the 20% of
total energy consumption at resting state although comprising only 2% of the body mass …

Astrocytic calcium and cAMP in neurodegenerative diseases

M Sobolczyk, T Boczek - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and
energy supply. Their unique morphological and functional features have recently brough …

Astrocytic IP3Rs: Beyond IP3R2

MW Sherwood, M Arizono, A Panatier… - Frontiers in cellular …, 2021 - frontiersin.org
Astrocytes are sensitive to ongoing neuronal/network activities and, accordingly, regulate
neuronal functions (synaptic transmission, synaptic plasticity, behavior, etc.) by the context …

Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity

A Denizot, M Arizono, UV Nägerl… - PLoS computational …, 2019 - journals.plos.org
Astrocytes, a glial cell type of the central nervous system, have emerged as detectors and
regulators of neuronal information processing. Astrocyte excitability resides in transient …