A 58-year-old man is found on laboratory testing to have a serum calcium level of 6.0 mg per
deciliter (normal range, 8.5 to 10.5), an albumin level of 3.9 g per deciliter, and a …

Purpose: To provide practice recommendations for the diagnosis and management of
hypoparathyroidism in adults. Methods: Key questions pertaining to the diagnosis and …

The life of patients with thalassemia has improved both in duration and in quality in
industrialized countries. Complications are still common and include heart disease (heart …

Hemoglobinopathies, including β-thalassemia and sickle cell disease (SCD), are common
genetic blood disorders. Endocrine disorders are frequent manifestations of organ damage …

Hypocalcemia (defined as total serum calcium lower than 8.5 mg/dl or as ionized serum
calcium lower than 4.7 mg/dl) is a relatively common metabolic abnormality observed in …

Thalassemia bone disease is a common and severe complication of thalassemia—an
inherited blood disorder due to mutations in the α or β hemoglobin gene. In its more severe …

Recently introduced chelation regimens that combine deferoxamine (DFO) and deferiprone
have been shown to have greater efficacy in promoting iron excretion than either chelator …

Thalassemia-associated osteoporosis constitutes a major complication in patients with
thalassemia. This review presents the existing studies on the treatment of thalassemia …

Beta thalassemia is the most common genetic blood disorder, characterized by reduced
production or complete absence of beta-globin chains. The combination of systematic red …

Osteoporosis in thalassaemia major (TM) represents a prominent cause of morbidity. The
mechanism of pathogenesis of bone disease (BD) in TM is multifactorial and complicated …