The peripheral nervous system (PNS) has remarkable regenerative abilities after injury.
Successful PNS regeneration relies on both injured axons and non-neuronal cells, including …

It has been 50years since Gross and Lapiere discovered collagenolytic activity during
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …

Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by duplication of peripheral myelin
protein 22 (PMP22) and is the most common hereditary peripheral neuropathy. CMT1A is …

Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms,
which could lead to severe functional impairments. Here we analyzed the characteristics of …

In this review we summarize the events known to occur after an injury in the peripheral
nervous system. We have focused on the Schwann cells, as they are the most important …

Nerve injury is a common and difficult clinical problem worldwide with a high disability rate.
Different from the central nervous system, the peripheral nervous system is able to …

Understanding the physiological role of any protease requires identification of both its
cleavage substrates and their relative cleavage efficacy as compared with other substrates …

The rapid and dynamic transcriptional changes of Schwann cells in response to injury are
critical to peripheral nerve repair, yet the epigenomic reprograming that leads to the …

Purpose Most patients who undergo surgery or experience a traumatic injury suffer from
acute pain that subsides once tissues heal. Nevertheless, the pain remains in 15-30% of …

Chronic and neuropathic pain are a widespread burden. Incomplete understanding of
underlying pathomechanisms is one crucial factor for insufficient treatment. Recently …