[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
LncRNA‐mediated posttranslational modifications and reprogramming of energy metabolism in cancer
YT Tan, JF Lin, T Li, JJ Li, RH Xu… - Cancer …, 2021 - Wiley Online Library
Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism
has historically been considered a general phenomenon of tumors. It is well recognized that …
has historically been considered a general phenomenon of tumors. It is well recognized that …
A new era in functional genomics screens
L Przybyla, LA Gilbert - Nature Reviews Genetics, 2022 - nature.com
The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …
human genome and then a detailed catalogue of human genome variation associated with …
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
H Li, Y Yang, W Hong, M Huang, M Wu… - Signal transduction and …, 2020 - nature.com
Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …
technologies has opened up the possibility of directly targeting and modifying genomic …
The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
[HTML][HTML] Long non-coding RNAs: from disease code to drug role
Y Chen, Z Li, X Chen, S Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …
participate in crucial physiological processes such as metabolism and immunity, and are …
Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis
J Lou, Y Hao, K Lin, Y Lyu, M Chen, H Wang, D Zou… - Molecular cancer, 2020 - Springer
Background Inactivation of the tumor suppressor p53 is critical for pathogenesis of glioma, in
particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds …
particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds …
Non-coding RNAs in cancer: Platforms and strategies for investigating the genomic “dark matter”
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …
Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β‐catenin signaling
X Tian, Y Wu, Y Yang, J Wang, M Niu, S Gao… - Molecular …, 2020 - Wiley Online Library
Tumor‐associated macrophages have important roles in hepatocellular carcinoma (HCC)
initiation and progression. Long noncoding RNAs (lncRNAs) have also been reported to be …
initiation and progression. Long noncoding RNAs (lncRNAs) have also been reported to be …