Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

GABAB receptors are broadly expressed in the nervous system and have been implicated in
a wide variety of neurological and psychiatric disorders. The cloning of the first GABAB …

Chemical manufacturing is often done at large facilities that require a sizable capital
investment and then produce key compounds for a finite period. We present an approach to …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Background Intervention to achieve alcohol abstinence represents the most effective
treatment for alcohol-dependent patients with liver cirrhosis; however, anticraving drugs …

Drug addiction manifests as a compulsive drive to take a drug despite serious adverse
consequences. This aberrant behaviour has traditionally been viewed as bad'choices' that …

Despite the generally held view that alcohol is an unspecific pharmacological agent, recent
molecular pharmacology studies demonstrated that alcohol has only a few known primary …

Symptoms of alcohol withdrawal syndrome (AWS) may develop within 6–24 h after the
abrupt discontinuation or decrease of alcohol consumption. Symptoms can vary from …

Alcohol dependence is an increasing and pervasive problem. Alcohol withdrawal symptoms
are a part of alcohol dependence syndrome and are commonly encountered in general …

Alcohol use disorders (AUDs) is one of the leading causes of disease and disability in
almost all European countries. Among the alcohol-related diseases, alcoholic liver disease …