ABSTRACT Introduction The concept of Digital Twins (DTs) translated to drug development
and clinical trials describes virtual representations of systems of various complexities …

Digital twins are virtual replicas of physical objects or systems. This new technology is
increasingly being adopted in industry to improve the monitoring and efficiency of products …

Virtual patients and digital patients/twins are two similar concepts gaining increasing
attention in health care with goals to accelerate drug development and improve patients' …

Bispecific T cell engagers (bsTCEs) have emerged as a promising class of cancer
immunotherapy. Several bsTCEs have achieved marketing approval; dozens more are …

Project Optimus is a US Food and Drug Administration Oncology Center of Excellence
initiative aimed at reforming the dose selection and optimization paradigm in oncology drug …

Despite recent progress in adoptive T cell therapy for cancer, understanding and predicting
the kinetics of infused T cells remains a challenge. Multiple factors can impact the …

Quantitative systems pharmacology (QSP) has been an important tool to project safety and
efficacy of novel or repurposed therapies for the SARS‐CoV‐2 virus. Here, we present a …

Model‐informed approaches provide a quantitative framework to integrate all available
nonclinical and clinical data, thus furnishing a totality of evidence approach to drug …

Bispecific T‐cell engagers (bsTCEs) have emerged as a promising class of cancer
immunotherapy. BsTCEs enable physical connections between T cells and tumor cells to …

Background The concept of digital twins, widely adopted in industry, is entering health care.
However, there is a lack of consensus on what constitutes the digital twin of a patient …