Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts
produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be …

Diseases/conditions with diverse etiology, such as hemoglobinopathies, hereditary
hemochromatosis and menopause, could lead to chronic iron accumulation. This condition …

Osteogenic differentiation of multipotent mesenchymal stem cells (MSCs) plays a crucial role
in bone remodeling. Numerous studies have described the deleterious effect of iron …

Iron is an essential element for human life. However, it is a pro-oxidant agent capable of
reacting with hydrogen peroxide. An iron overload can cause cellular changes, such as …

Estrogen deficiency has been regarded as the main causative factor in menopausal
symptoms and diseases. Here, we show that although estrogen decreases by 90%, a …

In 87 patients with hereditary hemochromatosis, osteoporosis was detected in 25%, and
osteopenia in 41%. Bone mineral density was independently associated with BMI, ALP …

Hemochromatosis is a known cause of osteoporosis, and iron overload has deleterious
effects on bone. Although iron overload and its association with osteoporosis has long been …

Iron is indispensable for human life. However, it is also potentially toxic, since it catalyzes the
formation of harmful oxidative radicals in unbound form and may facilitate pathogen growth …

Hereditary hemochromatosis (HH) is a genetic disorder of iron overload and subsequent
organ damage. Five types of HH are known, classified by age of onset, genetic cause …

Recently introduced chelation regimens that combine deferoxamine (DFO) and deferiprone
have been shown to have greater efficacy in promoting iron excretion than either chelator …