In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Immune checkpoint inhibitors have revolutionized medical oncology, although currently only
a subset of patients has a response to such treatment. A compelling body of evidence …

All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Simple Summary Several anti-angiogenic drugs have been approved for cancer treatment,
alone or in combination with other anti-tumoral agents. Angiogenesis inhibitors cause drug …

Key Issues in Conducting a Meta-Analysis of Gene Expression Microarray Datasets | PLOS
Medicine Skip to main content Advertisement PLOS Medicine Browse Current Issue Journal …

Angiogenesis has been regarded as essential for tumor growth and progression. Studies of
many human tumors, however, suggest that their microcirculation may be provided by …

Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …

Spatially resolved transcriptomics involves a set of emerging technologies that enable the
transcriptomic profiling of tissues with the physical location of expressions. Although a …

Solid tumours need a blood supply, and a large body of evidence has previously suggested
that they can grow only if they induce the development of new blood vessels, a process …

Tumors can escape immunity through multiple mechanisms, one of which is by enforcing a
state of unresponsiveness of the tumor vasculature to inflammatory cytokines. This results in …