Endogenous retroviral promoter exaptation in human cancer
Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …
expression or mutational activation of oncogenes, as well as suppression/inactivation of …
Effects of retroviruses on host genome function
For millions of years, retroviral infections have challenged vertebrates, occasionally leading
to germline integration and inheritance as ERVs, genetic parasites whose remnants today …
to germline integration and inheritance as ERVs, genetic parasites whose remnants today …
The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences.
R Löwer, J Löwer, R Kurth - Proceedings of the National …, 1996 - National Acad Sciences
Human endogenous retroviruses (HERVs) are very likely footprints of ancient germ-cell
infections. HERV sequences encompass about 1% of the human genome. HERVs have …
infections. HERV sequences encompass about 1% of the human genome. HERVs have …
Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family
JL Blond, F Besème, L Duret, O Bouton, F Bedin… - Journal of …, 1999 - Am Soc Microbiol
The multiple sclerosis-associated retrovirus (MSRV) isolated from plasma of MS patients
was found to be phylogenetically and experimentally related to human endogenous …
was found to be phylogenetically and experimentally related to human endogenous …
HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression
S Srinivasachar Badarinarayan… - Nucleic Acids …, 2020 - academic.oup.com
Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory elements,
their role in modulating cellular immune responses remains poorly understood. Using an …
their role in modulating cellular immune responses remains poorly understood. Using an …
Endogenous double-stranded RNA
S Sadeq, S Al-Hashimi, CM Cusack, A Werner - Non-coding RNA, 2021 - mdpi.com
The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and
activation of repetitive elements in the genome. The transcription of endogenous …
activation of repetitive elements in the genome. The transcription of endogenous …
RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements
J Brosius - Gene, 1999 - Elsevier
While the significance of middle repetitive elements had been neglected for a long time,
there are again tendencies to ascribe most members of a given middle repetitive sequence …
there are again tendencies to ascribe most members of a given middle repetitive sequence …
Expression of human endogenous retrovirus k envelope transcripts in human breast cancer
F Wang-Johanning, AR Frost, GL Johanning… - Clinical Cancer …, 2001 - AACR
Purpose: We investigated the expression of human endogenous retroviral (HERV)
sequences in breast cancer. Experimental Design: Reverse transcription-PCR (RT-PCR) …
sequences in breast cancer. Experimental Design: Reverse transcription-PCR (RT-PCR) …
Evolutionary impact of transposable elements on genomic diversity and lineage-specific innovation in vertebrates
IA Warren, M Naville, D Chalopin, P Levin… - Chromosome …, 2015 - Springer
Since their discovery, a growing body of evidence has emerged demonstrating that
transposable elements are important drivers of species diversity. These mobile elements …
transposable elements are important drivers of species diversity. These mobile elements …
Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3)
DL Mager, DG Hunter, M Schertzer, JD Freeman - Genomics, 1999 - Elsevier
By screening the expressed sequence tag (EST) database, we identified transcripts of two
new human genes that are polyadenylated within a long terminal repeat (LTR) of the HERV …
new human genes that are polyadenylated within a long terminal repeat (LTR) of the HERV …