The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …

The germinal center (GC) is a unique histological structure found in peripheral lymphoid
organs. GCs provide an important source of humoral immunity by generating high affinity …

Abstract β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia result
from mutations in the adult HBB (β-globin) gene. Reactivating the developmentally silenced …

The cellular fate after infection with human coronaviruses (HCoVs) is typically death.
Previous data suggest, however, that the transcriptional state of an individual cell may …

Hematopoietic development is governed by the coordinated expression of lineage-and
differentiation stage-specific genes. Transcription factors play major roles in this process and …

Learning how critical cell regulatory pathways are controlled may lead to new opportunities
for cancer treatment. We recently identified the transcription factor Pokemon as a central …

ZBTB7A is a member of the POK family of transcription factors that possesses a POZ-domain
at the N-terminus and Krüppel-like zinc-finger at the c-terminus. ZBTB7A was initially …

Myc regulates to some degree every major process in the cell. Proliferation, growth,
differentiation, apoptosis, and metabolism are all under Myc control. In turn, these processes …

FBI-1 (also called Pokemon/ZBTB7A) is a BTB/POZ-domain Krüppel-like zinc-finger
transcription factor. Recently, FBI-1 was characterized as a proto-oncogenic protein, which …

Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell
disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF …