[HTML][HTML] Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced …
R Root-Bernstein - Pharmaceuticals, 2022 - mdpi.com
This paper proposes the design of combination opioid–adrenergic tethered compounds to
enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side …
enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side …
Endogenous opiates and behavior: 2011
RJ Bodnar - Peptides, 2012 - Elsevier
This paper is the thirty-fourth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2011 …
concerning the endogenous opioid system. It summarizes papers published during 2011 …
New therapeutic uses for an alpha2 adrenergic receptor agonist–dexmedetomidine in pain management
X Zhang, X Bai - Neuroscience Letters, 2014 - Elsevier
Dexmedetomidine was initially approved for clinical use as a sedative. Its development in
pain management has been limited. Dexmedetomidine has analgesic effects and analgesic …
pain management has been limited. Dexmedetomidine has analgesic effects and analgesic …
Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine‐tolerant rats
X Jia, A Zhang, Z Li, X Peng, X Tian… - Journal of …, 2021 - Wiley Online Library
The adverse side effects of opioids, especially antinociceptive tolerance, limit their clinical
application. A recent study reported that platelet‐derived growth factor receptor β (PDGFRβ) …
application. A recent study reported that platelet‐derived growth factor receptor β (PDGFRβ) …
[HTML][HTML] Effect of intra-articular dexmedetomidine on experimental osteoarthritis in rats
LMRS Gomes, NG Czeczko, RLTM Araújo… - Plos one, 2021 - journals.plos.org
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the
drugs used. Dexmedetomidine via the intra-articular (ia) route might be an option for the …
drugs used. Dexmedetomidine via the intra-articular (ia) route might be an option for the …
Enhancing fentanyl antinociception and preventing tolerance with α-2 adrenoceptor agonists in rats
DY Pehlivan, AY Kara, A Koyu, F Simsek - Behavioural Brain Research, 2024 - Elsevier
Fentanyl (FEN) is a potent opioid analgesic used for pain management. Opioid analgesic
tolerance poses a significant challenge to the clinical utility of opioid agonists. Preventing …
tolerance poses a significant challenge to the clinical utility of opioid agonists. Preventing …
Upregulation of μ-opioid receptor in the rat spinal cord contributes to the α2-adrenoceptor agonist dexmedetomidine-induced attenuation of chronic morphine …
P Zhang, J Bu, X Wu, L Deng, M Chi, C Ma… - Journal of Pain …, 2020 - Taylor & Francis
Background Sustained morphine treatment for cancer pain has been limited due to
analgesic tolerance. Opioid receptor internalization and desensitization mediated by …
analgesic tolerance. Opioid receptor internalization and desensitization mediated by …
[HTML][HTML] Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists
A Altun, K Yildirim, E Ozdemir, I Bagcivan… - The journal of …, 2015 - Springer
Cannabinoid CB1 and CB2 receptor antagonists may be useful for their potential to increase
or prolong opioid analgesia while attenuating the development of opioid tolerance. The aim …
or prolong opioid analgesia while attenuating the development of opioid tolerance. The aim …
The role of the cannabinoid system in opioid analgesia and tolerance
E Ozdemir - Mini Reviews in Medicinal Chemistry, 2020 - ingentaconnect.com
Opioid receptor agonist drugs, such as morphine, are very effective for treating chronic and
severe pain; but, tolerance can develop with long-term use. Although there is a lot of …
severe pain; but, tolerance can develop with long-term use. Although there is a lot of …
Safety and efficacy of dexmedetomidine in breast surgeries: a systematic review and meta-analysis
Purpose Pain control during and after breast surgery is still a challenging task.
Dexmedetomidine (DEX) is considered as a sedative agent that is widely used perineurally …
Dexmedetomidine (DEX) is considered as a sedative agent that is widely used perineurally …