Melatonin as an antioxidant: under promises but over delivers
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …
number of circumstances. It achieves this action via a variety of means: direct detoxification …
Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas
Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …
retained throughout evolution such that it may be or may have been present in every species …
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …
[HTML][HTML] The urgent need to develop novel strategies for the diagnosis and treatment of snakebites
HF Williams, HJ Layfield, T Vallance, K Patel… - Toxins, 2019 - mdpi.com
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of
100,000 people per year. Additionally, many millions of survivors also suffer through …
100,000 people per year. Additionally, many millions of survivors also suffer through …
Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system
SK NaveenKumar, M Hemshekhar… - Journal of pineal …, 2020 - Wiley Online Library
Melatonin is a chronobiotic hormone, which can regulate human diseases like cancer,
atherosclerosis, respiratory disorders, and microbial infections by regulating redox system …
atherosclerosis, respiratory disorders, and microbial infections by regulating redox system …
[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
[HTML][HTML] Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin
Reactive oxygen species (ROS) are capable of inducing cell death or apoptosis. Recently,
we demonstrated that lipid-ROS can mediate ferroptosis and activation of human platelets …
we demonstrated that lipid-ROS can mediate ferroptosis and activation of human platelets …
Targetting ferroptosis for blood cell-related diseases
Z Chen, J Jiang, N Fu, L Chen - Journal of Drug Targeting, 2022 - Taylor & Francis
Ferroptosis is an iron-dependent cell death pathway and participates in various diseases.
Current evidence suggests that ferroptosis can obviously affect the function of blood cells …
Current evidence suggests that ferroptosis can obviously affect the function of blood cells …
Inner speech is used to mediate short-term memory, but not planning, among intellectually high-functioning adults with autism spectrum disorder
Evidence regarding the use of inner speech by individuals with autism spectrum disorder
(ASD) is equivocal. To clarify this issue, the current study employed multiple techniques and …
(ASD) is equivocal. To clarify this issue, the current study employed multiple techniques and …
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19
Severe COVID-19 is associated with the dynamic changes in coagulation parameters.
Coagulopathy is considered as a major extra-pulmonary risk factor for severity and mortality …
Coagulopathy is considered as a major extra-pulmonary risk factor for severity and mortality …