Novel insights into mesothelioma biology and implications for therapy
Malignant mesothelioma is a universally lethal cancer that is increasing in incidence
worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and …
worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and …
BAP1 and cancer
M Carbone, H Yang, HI Pass, T Krausz… - Nature Reviews …, 2013 - nature.com
BAP1 is a deubiquitylase that is found associated with multiprotein complexes that regulate
key cellular pathways, including the cell cycle, cellular differentiation, cell death …
key cellular pathways, including the cell cycle, cellular differentiation, cell death …
Frequency of germline mutations in cancer susceptibility genes in malignant mesothelioma
V Panou, M Gadiraju, A Wolin, CM Weipert… - Journal of Clinical …, 2018 - ascopubs.org
Purpose The aim of the current study was to determine the prevalence and clinical
predictors of germline cancer susceptibility mutations in patients with malignant …
predictors of germline cancer susceptibility mutations in patients with malignant …
Malignant mesothelioma and its non-asbestos causes
RL Attanoos, A Churg… - … of pathology & …, 2018 - meridian.allenpress.com
Context.—Although many mesotheliomas are related to asbestos exposure, not all are, and
there is increasing information on other causes of mesothelioma. Objective.—To provide a …
there is increasing information on other causes of mesothelioma. Objective.—To provide a …
Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma
A Scherpereel, P Astoul, P Baas… - European …, 2010 - Eur Respiratory Soc
Malignant pleural mesothelioma (MPM) is a rare tumour but with increasing incidence and a
poor prognosis. In 2008, the European Respiratory Society/European Society of Thoracic …
poor prognosis. In 2008, the European Respiratory Society/European Society of Thoracic …
Malignant mesothelioma: facts, myths, and hypotheses
M Carbone, BH Ly, RF Dodson… - Journal of cellular …, 2012 - Wiley Online Library
Malignant mesothelioma (MM) is a neoplasm arising from mesothelial cells lining the
pleural, peritoneal, and pericardial cavities. Over 20 million people in the US are at risk of …
pleural, peritoneal, and pericardial cavities. Over 20 million people in the US are at risk of …
Asbestos and other hazardous fibrous minerals: potential exposure pathways and associated health risks
There are six elongate mineral particles (EMPs) corresponding to specific dimensional and
morphological criteria, known as asbestos. Responsible for health issues including …
morphological criteria, known as asbestos. Responsible for health issues including …
Malignant pleural mesothelioma
AS Tsao, I Wistuba, JA Roth, HL Kindler - Journal of clinical oncology, 2009 - ascopubs.org
Malignant pleural mesothelioma (MPM) is a deadly disease that occurs in 2,000 to 3,000
people each year in the United States. Although MPM is an extremely difficult disease to …
people each year in the United States. Although MPM is an extremely difficult disease to …
TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
H Yang, M Bocchetta, B Kroczynska… - Proceedings of the …, 2006 - National Acad Sciences
Asbestos is the main cause of human malignant mesothelioma (MM). In vivo, macrophages
phagocytize asbestos and, in response, release TNF-α and other cytokines that contribute to …
phagocytize asbestos and, in response, release TNF-α and other cytokines that contribute to …
[HTML][HTML] Consensus report of the 2015 Weinman international conference on mesothelioma
Abstract On November 9 and 10, 2015, the International Conference on Mesothelioma in
Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of …
Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of …