Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …

This review will cover the developments in the chemistry of phenanthroline-based ligands in
the last 10–15 years. 1, 10-Phenanthroline (phen) is a classic ligand in coordination …

G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-
association of guanines, and G4s are distributed widely across the genome. G4 participates …

Although many biochemical and structural studies have demonstrated that DNA sequences
containing runs of adjacent guanines spontaneously fold into G-quadruplex DNA structures …

The 3′‐ends of human chromosomal DNA terminate in short single‐stranded guanine‐rich
tandem‐repeat sequences. In cancer cells, these are associated with the telomere …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …