Background The clinical picture, but also neuroimaging findings, suggested the brainstem
and midbrain structures as possible driving or generating structures in migraine. Findings …

Deep brain stimulation (DBS) of the subthalamic nucleus, pallidum, and thalamus is an
established therapy for various movement disorders. Limbic targets have also been …

Objective Deep brain stimulation (DBS) is a treatment option for refractory chronic cluster
headache (CCH). Despite several recent prospective case series reporting a good outcome …

Primary headache disorders including migraine, cluster headache, and tension-type
headache are among the most common disabling diseases worldwide. The unclear …

PURPOSE OF REVIEW The trigeminal autonomic cephalalgias (TACs) are relatively rare,
but they represent a distinct set of syndromes that are important to recognize. Despite their …

Abstract Purpose of Review The treatment of cluster headache has evolved to include a
handheld neuromodulation device and a monoclonal antibody in addition to more traditional …

Background Calcitonin gene-related peptide has shown to play a central role in cluster
headache (CH) pathophysiology. A clinical trial with galcanezumab was carried out in …

Abstract Purpose of Review In this narrative review, the current literature on
neurostimulation methods in the treatment of chronic cluster headache is evaluated. These …

Background: Chronic cluster headache (CCH) is a severe and debilitating sub-type of
trigeminal autonomic cephalalgia that can be resistant to medical management and …

Responsive neurostimulation (RNS) has well-established efficacy in patients with
identifiable seizure foci. Emerging evidence suggests the feasibility of expanding this …