[HTML][HTML] PRMT5 function and targeting in cancer
H Kim, AR Ze'ev - Cell stress, 2020 - ncbi.nlm.nih.gov
Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …
cancer development, progression and therapy-response. Here we discuss the function of …
A glimpse of the mechanisms related to renal fibrosis in diabetic nephropathy
LF Zeng, Y Xiao, L Sun - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
Diabetic nephropathy (DN) is a common kidney disease in people with diabetes, which is
also a serious microvascular complication of diabetes and the main cause of end-stage …
also a serious microvascular complication of diabetes and the main cause of end-stage …
[HTML][HTML] Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth
Abstract Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme
that mainly represses transcription of target genes via symmetric dimethylation of arginine …
that mainly represses transcription of target genes via symmetric dimethylation of arginine …
[HTML][HTML] Role of protein arginine methyltransferase 5 in human cancers
W Xiao, X Chen, L Liu, Y Shu, M Zhang… - Biomedicine & …, 2019 - Elsevier
Protein arginine methyltransferases (PRMTs) play important roles in protein methylation.
PRMT5 is the major type II arginine methyltransferase that catalyzes the transfer of two …
PRMT5 is the major type II arginine methyltransferase that catalyzes the transfer of two …
[HTML][HTML] WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response
J Li, R Zhang, C Wang, J Zhu, M Ren, Y Jiang… - nature …, 2023 - nature.com
Abstract RIG-I-MAVS signaling pathway plays a crucial role in defending against pathogen
infection and maintaining immune balance. Upon detecting viral RNA, RIG-I triggers the …
infection and maintaining immune balance. Upon detecting viral RNA, RIG-I triggers the …
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
M Rengasamy, F Zhang, A Vashisht… - Nucleic acids …, 2017 - academic.oup.com
We observed overexpression and increased intra-nuclear accumulation of the
PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells …
PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells …
NF-Y in cancer: Impact on cell transformation of a gene essential for proliferation
NF-Y is a ubiquitous heterotrimeric transcription factor with a binding affinity for the CCAAT
consensus motif, one of the most common cis-acting element in the promoter and enhancer …
consensus motif, one of the most common cis-acting element in the promoter and enhancer …
[HTML][HTML] The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5
Abstract Protein arginine methyltransferase 5 (PRMT5) is an important member of the
protein arginine methyltransferase family that regulates many cellular processes through …
protein arginine methyltransferase family that regulates many cellular processes through …
Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy
Introduction: Exploration in the field of epigenetics has revealed the diverse roles of the
protein arginine methyltransferase (PRMT) family of proteins in multiple disease states …
protein arginine methyltransferase (PRMT) family of proteins in multiple disease states …
Discovery and biological characterization of PRMT5: MEP50 protein–protein interaction inhibitors
Protein arginine methyltransferase 5 (PRMT5) is a master epigenetic regulator and an
extensively validated therapeutic target in multiple cancers. Notably, PRMT5 is the only …
extensively validated therapeutic target in multiple cancers. Notably, PRMT5 is the only …