Genome-scale models in human metabologenomics
A Mardinoglu, BØ Palsson - Nature Reviews Genetics, 2024 - nature.com
Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …
study the genetic and environmental factors that influence metabolism. These multi-omics …
Deep learning meets metabolomics: a methodological perspective
P Sen, S Lamichhane, VB Mathema… - Briefings in …, 2021 - academic.oup.com
Deep learning (DL), an emerging area of investigation in the fields of machine learning and
artificial intelligence, has markedly advanced over the past years. DL techniques are being …
artificial intelligence, has markedly advanced over the past years. DL techniques are being …
Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes
The gut microbiota is crucial in the regulation of bile acid (BA) metabolism. However, not
much is known about the regulation of BAs during progression to type 1 diabetes (T1D) …
much is known about the regulation of BAs during progression to type 1 diabetes (T1D) …
[HTML][HTML] Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …
Circulating sphingolipids in insulin resistance, diabetes and associated complications
SM Hammad, MF Lopes-Virella - International Journal of Molecular …, 2023 - mdpi.com
Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …
diabetes, as well as in the development of both micro-and macro-vascular complications …
Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine
Recent advancements in omics technologies have generated a wealth of biological data.
Integrating these data within mathematical models is essential to fully leverage their …
Integrating these data within mathematical models is essential to fully leverage their …
EVOO supplement prevents type 1 diabetes by modulating gut microbiota and serum metabolites in NOD mice
Aims Extra virgin olive oil (EVOO) is the highest quality olive oil available and has been
shown to regulate postprandial blood glucose in patients with type 1 diabetes (T1D) …
shown to regulate postprandial blood glucose in patients with type 1 diabetes (T1D) …
[HTML][HTML] Systems biology approaches to study lipidomes in health and disease
Lipids have many important biological roles, such as energy storage sources, structural
components of plasma membranes and as intermediates in metabolic and signaling …
components of plasma membranes and as intermediates in metabolic and signaling …
Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is
associated with multiple metabolic disturbances, yet the metabolic pathways underlying its …
associated with multiple metabolic disturbances, yet the metabolic pathways underlying its …
Circulating free fatty acid and phospholipid signature predicts early rapid kidney function decline in patients with type 1 diabetes
F Afshinnia, TM Rajendiran, C He, J Byun… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVES Patients with type 1 diabetes (T1D) exhibit modest lipid abnormalities as
measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid …
measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid …