The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)

DM Tanase, EM Gosav, CF Costea… - Journal of diabetes …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …

Targeting the progression of chronic kidney disease

M Ruiz-Ortega, S Rayego-Mateos, S Lamas… - Nature Reviews …, 2020 - nature.com
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

[HTML][HTML] SGLT-2 inhibitors in NAFLD: expanding their role beyond diabetes and cardioprotection

T Androutsakos, N Nasiri-Ansari, AD Bakasis… - International journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is an 'umbrella'term, comprising a spectrum
ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and …

[HTML][HTML] Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer

H Wang, Z Lu, X Zhao - Journal of hematology & oncology, 2019 - Springer
Hepatocellular carcinoma (HCC, also called primary liver cancer) is one of the most fatal
cancers in the world. Due to the insidiousness of the onset of HCC and the lack of effective …

Extracellular vesicles as biomarkers in liver diseases: a clinician's point of view

S Thietart, PE Rautou - Journal of hepatology, 2020 - Elsevier
Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and
microRNAs. They can originate from both healthy and stressed cells, and provide a …

[HTML][HTML] NAFLD as a continuum: from obesity to metabolic syndrome and diabetes

AF Godoy-Matos, WS Silva Júnior… - Diabetology & metabolic …, 2020 - Springer
Background The prevalence of non-alcoholic fatty liver disease (NAFLD) has been
increasing rapidly. It is nowadays recognized as the most frequent liver disease, affecting a …

Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management

T Marjot, A Moolla, JF Cobbold, L Hodson… - Endocrine …, 2020 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …

[PDF][PDF] Ipragliflozin improves the hepatic outcomes of patients with diabetes with NAFLD

H Takahashi, T Kessoku, M Kawanaka… - Hepatology …, 2022 - Wiley Online Library
Sodium glucose cotransporter‐2 inhibitors (SGLT2is) are now widely used to treat diabetes,
but their effects on nonalcoholic fatty liver disease (NAFLD) remain to be determined. We …

Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: a common comorbidity associated with severe complications

AJ Scheen - Diabetes & metabolism, 2019 - Elsevier
Patients with type 2 diabetes mellitus (T2DM) are exposed to non-alcoholic fatty liver
disease (NAFLD), a comorbidity associated with cardiovascular disease and chronic kidney …

SGLT-2 inhibitors and GLP-1 receptor agonists in metabolic dysfunction-associated fatty liver disease

JS Moon, JH Hong, YJ Jung, E Ferrannini… - Trends in Endocrinology …, 2022 - cell.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition that
affects nearly one billion people globally, characterized by triacylglycerol accumulation in …