Abstract The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-
coding RNA genes and is globally regulated by Mediator—a large, conformationally flexible …

Whole-genome sequence assemblies are now available for seven different animals,
including nematode worms, mice and humans. Comparative genome analyses reveal a …

Networks have become a key approach to understanding systems of interacting objects,
unifying the study of diverse phenomena including biological organisms and human …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

The C-terminal repeat domain (CTD), an unusual extension appended to the C terminus of
the largest subunit of RNA polymerase II, serves as a flexible binding scaffold for numerous …

Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II)
transcription system–it is needed for the system to respond to a transcriptional activator …

The peroxisome proliferator-activated receptor α (PPARα, or NR1C1) is a nuclear hormone
receptor activated by a structurally diverse array of synthetic chemicals known as …

Lignin is a complex phenolic polymer that is deposited in the secondary cell wall of all
vascular plants. The evolution of lignin is considered to be a critical event during vascular …

The multisubunit Mediator, comprising∼ 30 distinct proteins, plays an essential role in gene
expression regulation by acting as a bridge between DNA-binding transcription factors and …

The CDK8 kinase module (CKM) is a conserved, dissociable Mediator subcomplex whose
component subunits were genetically linked to the RNA polymerase II (RNAPII) C-terminal …