Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …

Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …

Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …

The availability of the human and mouse genome sequences has allowed the identification
and comparison of their respective degradomes—the complete repertoire of proteases that …

Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …

BACKGROUND/AIMS: Portal vein thrombosis in patients with liver cirrhosis is usually
associated to hepatocellular carcinoma. Clinical presentation of non-neoplastic portal vein …

The emerging discoveries on the link between polyadenylation and disease states underline
the need to fully characterize genome-wide polyadenylation states. Here, we report …

An efficient and high yielding expression system is required to produce recombinant
proteins. Furthermore, the transient expression system can be used to identify the …