Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …

The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly.
Increasing interest in the cerebellum as a participant in higher cognitive processes and as a …

The glial cells of the cerebellum, and particularly astrocytes and oligodendrocytes, are
characterized by a remarkable phenotypic variety, in which highly peculiar morphological …

Granule cell migration influences the laminar structure of the cerebellum and thereby affects
cerebellum function. Bergmann glia are derived from radial glial cells and aid in granule cell …

The calcium-sensing receptor (CaSR) is a widely expressed homodimeric G-protein coupled
receptor structurally related to the metabotropic glutamate receptors and GPRC6A. In …

Sonic Hedgehog (SHH) signaling at primary cilia drives the proliferation and progression of
a subset of medulloblastomas, the most common malignant paediatric brain tumor. Severe …

Recurrent mutations in chromatin modifiers are specifically prevalent in adolescent or adult
patients with Sonic hedgehog-associated medulloblastoma (SHH MB). Here, we report that …

Evolution of complex behaviors in higher vertebrates and primates require the development
of sophisticated neuronal circuitry and the expansion of brain surface area to accommodate …

Integrins mediate cell adhesion by providing a link between the actin cytoskeleton and the
extracellular matrix. As well as acting to anchor cells, integrin adhesions provide sensory …

MicroRNAs (miRNAs) have important roles in the development of the central nervous system
(CNS). Several reports indicate that tissue development and cellular differentiation in the …