Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …

Bacterial specialized metabolites are increasingly recognized as important factors in animal–
microbiome interactions: for example, by providing the host with chemical defenses. Even in …

Complex peptide natural products exhibit diverse biological functions and a wide range of
physico-chemical properties. As a result, many peptides have entered the clinics for various …

Lasso peptides are a class of ribosomally synthesized and post-translationally modified
peptides (RiPPs) that feature an isopeptide bond and a distinct lariat fold. A growing number …

Marine sponges are prolific sources of unique bioactive natural products. The sponge
Theonella swinhoei is represented by several distinct variants with largely nonoverlapping …

Covering: up to 2018 Symbiotic microbes interact with animals, often by producing natural
products (specialized metabolites; secondary metabolites) that exert a biological role. A …

Genomic and functional analyses of bacterial sponge symbionts belonging to the
uncultivated candidate genus 'Entotheonella'has revealed them as the prolific producers of …

Lasso peptides are a class of ribosomally synthesized and post-translationally modified
peptides (RiPPs) that feature an isopeptide bond and a distinct lariat fold. A growing number …