Free-radicals (Oxygen and Nitrogen species) are formed in mitochondria during the
oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an …

Inflammation is a complex systemic response evolved to cope with cellular injury, either due
to infectious agents or, in general, with sporadic events challenging tissue integrity and …

Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene
methyl-CpG-binding protein 2 (MECP2), a ubiquitously expressed transcriptional regulator …

In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …

Normal brain functioning relies on high aerobic energy production provided by
mitochondria. Failure to supply a sufficient amount of energy, seen in different brain …

Current evidence indicates that certain immune molecules such as components of the
complement system are directly involved in neurobiological processes related to brain …

Rare diseases are very difficult to study mechanistically and to develop therapies for
because of the scarcity of patients. Here, the rare neuro-metabolic disorder Rett syndrome …

A significant body of evidence supports the multifactorial etiology of neurodevelopmental
disorders (NDDs) affecting children. The present review focuses on early exposure to …

Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily caused by
mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition …

First described over 50 years ago, Rett syndrome (RTT) is a neurodevelopmental disorder
caused primarily by mutations of the X-linked MECP2 gene. RTT affects predominantly …