Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

Background Meningeal and other trigeminal nociceptors are thought to play important roles
in the initiation of migraine headache. Currently, the only approved peripherally …

The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of
sensory neurons with their peripheral and central processes. Most neurons are surrounded …

Treating pain by inhibiting ATP activation of P2X3-containing receptors heralds an exciting
new approach to pain management, and Afferent's program marks the vanguard in a new …

Background: Calcitonin gene-related peptide (CGRP), a neuropeptide released from
trigeminal nerves, is implicated in the underlying pathology of temporomandibular joint …

Botulinum neurotoxin type-A (BoNT-A) is clinically used for patients with pain disorders and
dystonia. The precise mechanism whereby BoNT-A controls pain remains elusive. Here, we …

Extracellular nucleosides and nucleotides have widespread functions in responding to
physiological stress. The “purinome” encompasses 4 G-protein-coupled receptors (GPCRs) …

Odontoblasts are the dental pulp cells responsible for the formation of dentin. In addition,
accumulating data strongly suggest that they can also function as sensory cells that mediate …

The tooth has an unusual sensory system that converts external stimuli predominantly into
pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non …