[HTML][HTML] From theory to practice: translating whole-genome sequencing (WGS) into the clinic

F Balloux, OB Brynildsrud, L Van Dorp, LP Shaw… - Trends in …, 2018 - cell.com
Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting
infections and providing patients with optimal drug regimens require timely strain …

[HTML][HTML] Bacterial genome sequencing in clinical microbiology: a pathogen-oriented review

F Tagini, G Greub - European journal of clinical microbiology & infectious …, 2017 - Springer
In recent years, whole-genome sequencing (WGS) has been perceived as a technology with
the potential to revolutionise clinical microbiology. Herein, we reviewed the literature on the …

A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study

D Gu, N Dong, Z Zheng, D Lin, M Huang… - The Lancet infectious …, 2018 - thelancet.com
Summary Background Hypervirulent Klebsiella pneumoniae strains often cause life-
threatening community-acquired infections in young and healthy hosts, but are usually …

[HTML][HTML] Novel subclone of carbapenem-resistant Klebsiella pneumoniae sequence type 11 with enhanced virulence and transmissibility, China

K Zhou, T Xiao, S David, Q Wang, Y Zhou… - Emerging infectious …, 2020 - ncbi.nlm.nih.gov
We aimed to clarify the epidemiologic and clinical importance of evolutionary events that
occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP …

[HTML][HTML] Identification of a salmonellosis outbreak by means of molecular sequencing

EK Lienau, E Strain, C Wang, J Zheng… - … England Journal of …, 2011 - Mass Medical Soc
Identification of a Salmonellosis Outbreak by Means of Molecular Sequencing | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

[HTML][HTML] Risk factors and clinical outcomes of hypervirulent Klebsiella pneumoniae induced bloodstream infections

J Li, J Ren, W Wang, G Wang, G Gu, X Wu… - European Journal of …, 2018 - Springer
The prevalence of hypervirulent Klebsiella pneumoniae (hvKP) is high in China, but clinical
characteristics and outcomes of hvKP induced bloodstream infections (BSIs) are not clear …

Comparison of core-genome MLST, coreSNP and PFGE methods for Klebsiella pneumoniae cluster analysis

F Gona, F Comandatore, S Battaglia… - Microbial …, 2020 - microbiologyresearch.org
In this work we compared the most frequently used Klebsiella pneumoniae typing methods:
PFGE, cgMLST and coreSNP. We evaluated the discriminatory power of the three methods …

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

J He, Q Shi, Z Chen, W Zhang, P Lan, Q Xu, H Hu… - Drug Resistance …, 2023 - Elsevier
Aims To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64
carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and …

Genome analysis of clinical multilocus sequence Type 11 Klebsiella pneumoniae from China

N Dong, R Zhang, L Liu, R Li, D Lin… - Microbial …, 2018 - microbiologyresearch.org
The increasing prevalence of KPC-producing Klebsiella pneumoniae strains in clinical
settings has been largely attributed to dissemination of organisms of specific multilocus …

[HTML][HTML] Chasing the landscape for intrahospital transmission and evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae

L Liu, N Lou, Q Liang, W Xiao, G Teng, J Ma, H Zhang… - Science Bulletin, 2023 - Elsevier
The spread of hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP) is a
global health concern. Here, we report the intrahospital colonization and spread of Hv …