Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common and best known monogenic small …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common monogenic disorder of the cerebral …

Objective To determine the frequency of distinctive EGF r cysteine altering NOTCH 3
mutations in the 60,706 exomes of the exome aggregation consortium (Ex AC) database …

Cysteine-altering missense variants (NOTCH3 cys) in one of the 34 epidermal growth-factor-
like repeat (EGFr) domains of the NOTCH3 protein are the cause of NOTCH3-associated …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease caused by …

The recent discovery that the prevalence of cysteine mutations in the NOTCH3 gene
responsible for CADASIL was more than 100 times higher in the general population than …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is originally featured with a strong clustering of mutations …

Background and Purpose—Predictors of clinical worsening in cerebral autosomal dominant
arteriopathy with subcortical infarcts and leukoencephalopathy remain unknown. This study …

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy) is caused by mutations in the NOTCH3 gene, affecting the number of …

Background and purpose In 2019, the Brain Prize crowned the discovery of CADASIL in the
1990s and research efforts on this archetypal small vessel disease of the brain over 40 …