The role of mitochondria in metabolism and cell death
H Vakifahmetoglu-Norberg, AT Ouchida… - … and biophysical research …, 2017 - Elsevier
Mitochondria are complex organelles that play a central role in energy metabolism, control
of stress responses and are a hub for biosynthetic processes. Beyond its well-established …
of stress responses and are a hub for biosynthetic processes. Beyond its well-established …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in aging and cancer
AV Kudryavtseva, GS Krasnov, AA Dmitriev… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …
growing older, and the incidence of cancer increases with age. There is no doubt about the …
Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy
N Ta, C Qu, H Wu, D Zhang, T Sun… - Proceedings of the …, 2022 - National Acad Sciences
Ferroptosis is an iron-dependent programmed necrosis characterized by glutathione (GSH)
depletion and lipid peroxidation (LPO). Armed with both the pro-and antiferroptosis …
depletion and lipid peroxidation (LPO). Armed with both the pro-and antiferroptosis …
Mitochondria and Iron: current questions
BT Paul, DH Manz, FM Torti, SV Torti - Expert review of hematology, 2017 - Taylor & Francis
Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …
biosynthetic, and regulatory functions and play a central role in iron metabolism …
The crosstalk between the gut microbiota and mitochondria during exercise
Many physiological changes occur in response to endurance exercise in order to adapt to
the increasing energy needs, mitochondria biogenesis, increased reactive oxygen species …
the increasing energy needs, mitochondria biogenesis, increased reactive oxygen species …
Glutathione and mitochondria
V Ribas, C García-Ruiz… - Frontiers in …, 2014 - frontiersin.org
Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …
[HTML][HTML] Pathogenesis and prevention of hepatic steatosis
Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …
Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins
The key role of mitochondria in oxidative metabolism and redox homeostasis explains the
link between mitochondrial dysfunction and the development of metabolic disorders …
link between mitochondrial dysfunction and the development of metabolic disorders …
Aging-Oxidative stress, antioxidants and computational modeling
F Hussain, HUR Kayani - Heliyon, 2020 - cell.com
Aging is a degenerative, biological, time-dependent, universally conserved process thus
designed as one of the highest known risk factors for morbidity and mortality. Every …
designed as one of the highest known risk factors for morbidity and mortality. Every …
[HTML][HTML] Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes
Objective Mitochondrial dysfunction, oxidative stress and chondrocyte death are important
contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we …
contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we …