Mitochondria are complex organelles that play a central role in energy metabolism, control
of stress responses and are a hub for biosynthetic processes. Beyond its well-established …

Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

Ferroptosis is an iron-dependent programmed necrosis characterized by glutathione (GSH)
depletion and lipid peroxidation (LPO). Armed with both the pro-and antiferroptosis …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Many physiological changes occur in response to endurance exercise in order to adapt to
the increasing energy needs, mitochondria biogenesis, increased reactive oxygen species …

Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …

Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …

The key role of mitochondria in oxidative metabolism and redox homeostasis explains the
link between mitochondrial dysfunction and the development of metabolic disorders …

Aging is a degenerative, biological, time-dependent, universally conserved process thus
designed as one of the highest known risk factors for morbidity and mortality. Every …

Objective Mitochondrial dysfunction, oxidative stress and chondrocyte death are important
contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we …